UNC Postdoctoral Position in RNA Epigenomics in Matera LabPosted: 02 22, 2017
Postdoctoral Position in RNA Epigenomics
A postdoctoral position is available in the laboratory of Dr. Gregory Matera in the Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill.
The Program is devoted to model-organism biology and it provides a highly collaborative environment, along with exceptional interdisciplinary opportunities for trainees. The Matera lab has broad interests in basic molecular mechanisms that regulate RNA processing and RNP assembly in vivo. Using Drosophila as our primary genetic system, we engineer BAC-based histone gene clusters to express specific histone mutants that prevent binding of effector proteins in chromatin. These studies will thus directly evaluate the contributions of specific histone PTMs to epigenetic regulation during development and neoplasia.
McKay D.J., Klusza S., Meers M.P., Penke T.J.R., Curry K.P., McDaniel S.L., Malek P.Y, Cooper S.W., Tatomer D.C., Lieb J.D., Strahl B.D., Duronio R.J. and Matera A.G. (2015). Interrogating the function of metazoan histones using engineered gene clusters. Developmental Cell 32: 373-386. PMCID: PMC4385256
Penke T.J.R., McKay D.J., Strahl B.D., Matera A.G. and Duronio R.J. (2016). Replication-dependent H3K9 is essential for formation of pericentromeric heterochromatin and transposon silencing, but not for completion of Drosophila development. Genes & Development 30: 1866-1880. PMID: 27566777
Meers M.P., Henriques T., Lavender C.J., McKay D.J., Strahl B.D., Duronio R.J., Adelman K. and Matera A.G. (2016). Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity. eLife (in revision).
We are looking for enthusiastic, highly motivated and creative individuals with a strong interest in epigenetics and chromatin biology. US Citizens and permanent residents can apply for initial funding through the UNC Lineberger Comprehensive Cancer Center. Successful candidates for this position are expected to have a PhD in the biological sciences, along with demonstrated experience in molecular genetics and genomics and/or Drosophila.
Applicants should send a single PDF file containing a cover letter, curriculum vitae, and a short (1-2 pg) summary of their previous research experience and future goals. CV should include contact information for three references. Send to Greg Matera: firstname.lastname@example.org.