Johns Hopkins Rheumatology PostdocPosted: 05 18, 2017
Postdoctoral Research Fellow, Johns Hopkins Rheumatology
The laboratory of Dr. Felipe Andrade at Johns Hopkins University School of Medicine is seeking highly motivated and innovative post-doctoral scientists interested in the study of mechanisms in autoimmune rheumatic diseases. The main focus of this lab is the pathogenesis of rheumatoid arthritis (RA), an autoimmune disease characterized by the appearance of unique antibodies that target citrullinated proteins. Our work uses integrative approaches by applying experimental immunology, molecular biology techniques, and proteomics to the study of patient samples. The overarching goal of the lab is to elucidate mechanisms that drive and dysregulate protein citrullination in patients with RA. In particular, we have identified host (complement and perforin) and bacterial-mediated membranolytic pathways that drive neutrophil cell death as key principles in the abnormal production of citrullinated autoantigens in this disease (Sci Transl Med 2013, 5:209ra150; Sci Transl Med 2016, 8:369ra176; Front Immunol 2016, 7:461). Our studies have also focused attention on the oral pathogen Aggregatibacter actinomycetemcomitans as a potential pathogenic link between periodontal disease, citrullination and RA (Sci Transl Med 2016, 8:369ra176). How host and bacterial membranolytic pathways dysregulate citrullination in patients and can be inhibited in RA is a current priority of this lab.
The Johns Hopkins Division of Rheumatology is ranked #1 in the US by World and News Report in the last 9 years.
Post-doctoral scientists interested in studying pathogenic mechanisms in rheumatoid arthritis.
Highly motivated applicants with a PhD or MD degree and significant experience in molecular and cellular biology, immunology or microbiology may apply.
Applications should be sent directly to Dr. Felipe Andrade (email@example.com), including curriculum vitae and names and contact information of three references. All applications will be considered until the position is filled. The Johns Hopkins University is an Affirmative Action/Equal Opportunity Employer. Salary will be commensurate with level of experience according to the scale of the National Institutes of Health.